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Un equipo de investigadores del Instituto de Biomedicina de Sevilla -IBiS-, ubicado en el Hospital Universitario Virgen del Rocío, ha descubierto un nuevo circuito que conduce a un incremento del crecimiento y malignidad de los tumores. El trabajo, que combina estudios con líneas celulares tumorales, modelos animales y bases de datos de pacientes tratados en el hospital sevillano, ha sido publicado recientemente en la revista científica Oncogene del Nature Publishing Group.

El microambiente tumoral está formado por células tanto tumorales como no tumorales, entre
las cuales existen muchas interacciones que contribuyen al desarrollo del tumor. Este trabajo de
investigación ha descubierto que la proteína fosfolipasa D2 (PLD2), la cual se expresa a niveles anormalmente altos en pacientes de cáncer de colon, es secretada por las células tumorales y altera a las no tumorales del microambiente, provocando en ellas senescencia.

En concreto, la senescencia consiste en una parada de la división celular de las células que lo sufren, pese a lo cual éstas son capaces de secretar una serie de factores que aumentan la capacidad tumorigénica de las células tumorales. Esto hace que se establezca un circuito entre células tumorales y no tumorales que conduce a un aumento del número de células madre tumorales, las cuales poseen una capacidad proliferativa mayor que las células tumorales normales y similar al de las células madre. En CamisetasSpreadshirt Roca Pedir Línea Escalada jq35RSLc4A

El trabajo ha sido realizado por la Dra. Muñoz- Galván como investigadora principal y liderado por el Dr. Amancio Carnero, investigador científico del CSIC. Los resultados del mismo son de gran importancia para conocer la biología de los tumores y que determinan su evolución. Además, la proteína PLD2 puede servir como diana terapéutica para el tratamiento del cáncer de colon y, potencialmente, de otros tipos de tumores.

Fuente: Fundación Andaluza para la Divulgación de la Innovación y el Conocimiento

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